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Thomas Jefferson returns to America from being the U.S. ambassador to France ("What'd I Miss"). In 1789, Jefferson and Hamilton debate the latter's financial proposals at a Cabinet meeting. Washington pulls Hamilton aside and tells him to figure out a compromise to win over Congress ("Cabinet Battle #1").Eliza and her family-along with Angelica, back from London-travel upstate during the summer, while Hamilton stays home to work on the compromise ("Take a Break"). Hamilton begins an affair with Maria Reynolds, making him vulnerable to her husband's blackmail ("Say No To This"). Hamilton, Jefferson, and James Madison create the Compromise of 1790 over a private dinner, exchanging Hamilton's financial plan for placing the country's permanent capital on the Potomac River. Burr is envious of Hamilton's sway in the government and wishes he had similar power ("The Room Where It Happens"). Burr switches political parties and defeats Philip Schuyler, making Hamilton now a rival ("Schuyler Defeated").In another Cabinet meeting, Jefferson and Hamilton argue over whether the United States should assist France in its conflict with Britain. President Washington ultimately agrees with Hamilton's argument for remaining neutral ("Cabinet Battle #2"). In the wake of this, Jefferson, Madison, and Burr decide to join forces to find a way to discredit Hamilton in Washington's eyes ("Washington on Your Side"). Washington decides to retire from the presidency, and Hamilton assists in writing a farewell address ("One Last Time").A flabbergasted King George receives word that George Washington has stepped down, and will be replaced by Paris signatory John Adams ("I Know Him"). John Adams becomes the second President and fires Hamilton, who publishes an inflammatory critique of the new president as a response ("The Adams Administration"). In the face of accusations of speculation of government funds by Jefferson, Madison, and Burr-and out of fear that his affair with Maria Reynolds will be used against him in his political career ("We Know")-Hamilton chooses to publicize his affair ("Hurricane") in the Reynolds Pamphlet ("The Reynolds Pamphlet"), damaging his relationship with Eliza. Eliza, in a heartbroken retaliation, burns all the letters Hamilton wrote her, trying to erase herself from history ("Burn"). Philip, instructed by Hamilton, challenges George Eacker to a duel and is critically injured ("Blow Us All Away") and dies ("Stay Alive (Reprise)"), causing a reconciliation between Alexander and Eliza ("It's Quiet Uptown").Hamilton's endorsement of Jefferson in the presidential election of 1800 ("The Election of 1800") results in further animosity between Hamilton and Burr, who challenges Hamilton to a duel via an exchange of letters ("Your Obedient Servant"). Hamilton writes his last letter in a rush while Eliza tells him to go back to bed ("Best of Wives and Best of Women"). Burr and Hamilton travel to New Jersey for the duel. During the duel, both Burr and Hamilton fire at each other after ten paces, with Hamilton intentionally missing (throwing away) his shot. Hamilton dies as a result, with Eliza and Angelica at his side. Burr laments that even though he survived, he is cursed to be remembered as the villain who killed Hamilton ("The World Was Wide Enough"). The musical closes with a reflection on historical memory, showing how Eliza kept Hamilton's legacy alive ("Who Lives, Who Dies, Who Tells Your Story").